- Charlie Sheen as Charlie Goodson
- Selma Blair as Kate Wales (1-25)
- Shawnee Smith as Jennifer Goodson
- Daniela Bobadilla as Sam Goodson
- Noureen DeWulf as Lacey
- Michael Arden as Patrick
- Derek Richardson as Nolan
- Martin Sheen as Martin Goodson
- Brian Austin Green as Sean
"Charlie Loses It At A Baby Shower"
"Charlie's Dad Starts to Lose It"
"Charlie and the Ex–Patient"
"Charlie's Dad Breaks Bad"
"Charlie & Jen Together Again"
"Charlie and Deception Therapy"
"Charlie Dates a Teacher"
"Charlie & Cee Lo"
"Charlie is an Expert Witness"